How do I post changes in the datatable back to the DB?

Const Con_string As String = "Data Source=(LOCAL);Initial Catalog=MyDB;Integrated Security=True"
Const Command_String As String = "select * from Samples"

Dim myDataAdapter As New SqlDataAdapter(Command_String, Conn_string)
Dim myDataTable As New DataTable
MyDataAdapter.Fill(MyDataTable)

'modify data table

'what command do I use to send the modified data back to MyDB